Neuropsychiatric Dysfunction In Multiple Sclerosis - Can sleep deprivation trigger a seizure? Yes, it can. Seizures are very sensitive to sleep patterns. Some people have their first and only seizures after an "all-nighter" at college or after not sleeping well for long periods. If you have epilepsy, lack of "good sleep" makes most people more likely to have seizures. It can even increase the intensity and length of seizures..